Anti-Rb (Ab-780) Antibody

Produced in rabbit as an unconjugated polyclonal reagent, this Antibodies.com primary antibody recognizes the retinoblastoma (Rb) tumor suppressor protein at an epitope referenced as Ab-780. Supplied as 100 µl of liquid, the antibody is validated for western blot (WB) and immunohistochemistry (IHC) workflows across human, mouse, and rat samples, supporting studies of cell cycle regulation, G1/S checkpoint control, and tumor biology where Rb expression levels are tracked.

The polyclonal format enables recognition of multiple epitopes on the Rb protein, useful when working with truncated splice variants, partially degraded lysates, or fixed tissue sections where epitope accessibility varies. The reagent is applied in retinoblastoma, osteosarcoma, small cell lung carcinoma, and other cancer models to characterize how tumor suppressive function is altered across disease stages and in response to therapeutic intervention.

For research use only, the antibody should be aliquoted to limit freeze-thaw cycles and stored refrigerated between uses, then titrated empirically for each application to balance signal strength against background in IHC and western blot protocols.