Anti-RASGRF1 Antibody

This polyclonal antibody from Antibodies.com targets RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1), a guanine nucleotide exchange factor that activates Ras GTPases and couples them to upstream signals through calcium/calmodulin and heterotrimeric G-protein pathways. Raised in rabbit and supplied as an IgG preparation, the unconjugated reagent is delivered in a 50 µl volume suited to multiple experimental workflows.

Validated for Western blot, immunohistochemistry, and immunofluorescence, the antibody detects endogenous RASGRF1 expression in human and mouse samples. Researchers studying Ras/MAPK pathway components, neuronal signaling, synaptic plasticity, or tumor cell proliferation commonly use this reagent to probe endogenous levels of the exchange factor in tissue sections and cell lysates.

The polyclonal format offers broader epitope coverage than monoclonal alternatives, which is helpful when investigating post-translational modifications or alternative splice variants of the target. Aliquot upon receipt and store refrigerated to preserve activity across repeated experiments; avoid repeated freeze-thaw cycles to maintain reagent performance. The IgG isotype works with standard secondary antibody reagents, and the unconjugated format enables flexible labeling for custom assay design, including immunoprecipitation workflows where native protein complexes must be captured.