Anti-RARA Antibody

Raised in rabbit against Retinoic Acid Receptor Alpha (RARA), this polyclonal reagent from Antibodies.com is supplied as 100µl of unconjugated antiserum and validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows. The target is a nuclear ligand-dependent transcription factor that mediates the cellular effects of retinoic acid, directing gene-expression programs that govern cell differentiation, embryonic development, and hematopoietic lineage commitment.

Researchers working on retinoic acid signaling, nuclear receptor biology, and transcriptional regulation use this antibody to probe RARA expression in human, mouse, and rat samples. The validated application set supports subcellular localization studies in fixed tissue sections, expression profiling of whole-cell lysates, and imaging of RARA distribution in cultured cells.

RARA is a clinically important target because the t(15;17) chromosomal translocation generates the PML-RARA fusion oncoprotein that drives acute promyelocytic leukemia (APL), so the antibody is widely used in APL research and related studies of myeloid differentiation and aberrant transcriptional control. Polyclonal reactivity across multiple RARA epitopes supports reproducible detection of the receptor in chromatin preparations, nuclear extracts, and whole-cell lysates common to retinoid signaling investigations.