Anti-RAPGEF3 Antibody

The Rabbit polyclonal antibody to RAPGEF3 from Antibodies.com is an unconjugated primary antibody directed against RAPGEF3, the cAMP-regulated guanine nucleotide exchange factor also known as EPAC1 that activates the Rap1 and Rap2 small GTPases.

Supplied as a 100 µl aliquot of rabbit polyclonal serum, this reagent has been validated for Western blot, immunohistochemistry, and immunofluorescence across human, mouse, and rat samples. The polyclonal format offers broad epitope coverage, which can be advantageous when detecting RAPGEF3 isoforms, splice variants, or post-translationally modified forms of the protein.

RAPGEF3 serves as a central node in cAMP signaling that operates independently of protein kinase A, governing integrin-mediated cell adhesion, pancreatic beta-cell insulin secretion, cardiac calcium handling, and endothelial barrier integrity. Research on EPAC1 has direct implications for studies of type 2 diabetes, vascular inflammation and permeability, cardiac pathophysiology, and tumor cell adhesion and metastasis, where EPAC1 inhibitors and activators are increasingly investigated as experimental tools.

For best results, refrigerate the antibody upon arrival, aliquot to limit freeze-thaw cycles, and protect from light. The product is intended for laboratory research use only and is not approved for diagnostic or therapeutic applications.