Anti-RAP1GAP Antibody

Raised in rabbit and supplied by Antibodies.com, this unconjugated polyclonal IgG reagent targets the RAP1GAP regulatory protein and is validated for Western blot detection of human samples. RAP1GAP acts as a GTPase-activating protein that accelerates GTP hydrolysis on RAP1, converting active RAP1-GTP to its inactive GDP-bound form and thereby modulating integrin signaling, cell-matrix adhesion, and junctional integrity. Researchers apply this antibody to follow changes in RAP1GAP expression across epithelial, endothelial, and tumor-derived cell lines, often as part of studies linking loss of RAP1GAP to invasive phenotypes. The reagent is affinity-purified, unconjugated for flexible secondary detection, and shipped as a liquid suspension with a 200 µl volume that supports multiple western blot experiments. Recommended workflows include standard reducing SDS-PAGE, transfer to nitrocellulose or PVDF membranes, and chemiluminescent or fluorescent readouts. The antibody is reactive specifically with human antigen and is intended for research use only.