Anti-RAP1B Antibody

Polyclonal rabbit IgG from Antibodies.com targets the Ras-family GTPase RAP1B in an unconjugated format supplied as a 100 µL vial, validated for western blot and immunohistochemistry across human, mouse, and rat samples. The reagent enables detection of the endogenous 184-amino-acid, approximately 21 kDa membrane-associated protein in cell lysates and formalin-fixed tissue sections, supporting comparative studies of small GTPase signaling in adhesion, migration, polarity, junction organization, and intracellular trafficking pathways. Delivered without a conjugated label, the antibody is paired in the laboratory with HRP- or fluorophore-conjugated secondary reagents and chromogenic or fluorescence detection chemistries selected by the user. Polyclonal recognition broadens coverage across multiple epitopes, an advantage when post-translational modification such as geranylgeranylation at Cys181 or phosphorylation at Ser179 might otherwise reduce monoclonal signal. Laboratories investigating platelet aggregation, neuronal polarity, integrin-mediated outside-in signaling, focal adhesion dynamics, or vesicle transport use this reagent to follow RAP1B abundance and subcellular localization in experimental models.