Anti-RANKL Antibody

This rabbit polyclonal antibody from Antibodies.com targets RANKL (TNFSF11), the TNF-family ligand that drives osteoclast differentiation through RANK signaling and is central to bone remodeling, cancer-related bone loss, and immune regulation. Supplied as 100 µl of unconjugated antiserum, it supports Western blot and ELISA workflows across Human, Mouse, and Rat samples in basic and translational research settings.

Bone biology researchers use this reagent to investigate osteoporosis mechanisms, osteoclastogenesis, periodontal bone resorption, metastatic bone disease, and the immunological roles of T-cell-expressed RANKL. It pairs naturally with osteoprotegerin (OPG) measurements to characterize the RANKL/OPG ratio, a key indicator in bone turnover studies and the mechanism of action of denosumab and related therapeutics. The unconjugated format allows flexible secondary labeling for immunoblotting, plate-based detection, and custom assay development.

Raised in rabbit host animals, the antibody recognizes endogenous RANKL in Human, Mouse, and Rat lysates and tissue homogenates, supporting comparative studies in murine disease models and human clinical specimens. Each vial is shipped refrigerated; storage upon arrival should keep the vial refrigerated, with working aliquots prepared to preserve activity across multiple freeze-thaw cycles. Long-term storage requires freezing the stock to maintain titer over time.