Anti-RANGAP1 Antibody

Ran GTPase-activating protein 1 (RANGAP1) sits at the heart of nucleocytoplasmic transport, accelerating GTP hydrolysis on Ran to recycle Ran-GDP at the cytoplasmic face of the nuclear pore complex. This rabbit polyclonal primary antibody from Antibodies.com, supplied unconjugated at 100 µl, is validated for western blot, immunohistochemistry, and immunofluorescence detection of human, mouse, and rat RANGAP1.

Because the reagent is unconjugated, researchers can pair it with HRP-, fluorophore-, or biotin-conjugated secondary antibodies of their choice for chromogenic, fluorescence, or chemiluminescent readouts. RANGAP1 is a critical effector of the Ran GTPase cycle and is essential for nuclear protein import, spindle assembly, kinetochore function, and proper mitotic exit. It is also a substrate for SUMO modification at the nuclear pore, making this antibody a useful tool for studying SUMOylation, NPC architecture, and cell-cycle signaling.

For long-term use, store the vial at -20 °C in working aliquots to limit freeze-thaw cycles and preserve antibody titer across repeated experiments in cancer cell biology, cell-cycle research, and studies of nuclear transport dysregulation.