Anti-RAMP2 Antibody

RAMP2 (Receptor Activity Modifying Protein 2) functions as an obligate accessory subunit of the AM1 adrenomedullin receptor, partnering with the calcitonin receptor-like receptor (CLR) on vascular endothelial cells and lymphatic endothelium. Signaling through this CLR/RAMP2 complex governs vasodilation, endothelial barrier integrity, and lymphangiogenesis, with documented roles in sepsis-associated vascular leakage, preeclampsia models, and heart failure pathology. The Antibodies.com rabbit polyclonal anti-RAMP2 reagent is packaged in a single-use vial containing 100 µl of unconjugated antiserum, validated for western blot and immunohistochemistry on human samples. Polyclonal recognition across multiple epitopes of the RAMP2 extracellular domain makes the antibody tolerant of formalin-fixed paraffin-embedded tissue as well as freshly lysed cell preparations, supporting use across archived biopsy collections and live-cell harvest workflows. The unconjugated format permits flexible pairing with horseradish peroxidase, alkaline phosphatase, biotin, or fluorophore-conjugated secondary reagents depending on detection chemistry. Storage guidance from Antibodies.com calls for refrigerated short-term holding with aliquoting and freezing at -20°C for longer-term retention to limit activity loss across freeze-thaw cycles. This reagent has been characterized for reactivity with human RAMP2 and is commonly deployed in studies of adrenomedullin axis activity, vascular inflammation, and lymphatic biology.