Anti-RAB5A Antibody

This recombinant rabbit monoclonal reagent from Antibodies.com recognizes RAB5A, a small Ras-related GTPase that governs early endosome biogenesis, homotypic endosome fusion, and receptor-mediated endocytosis. RAB5A cycles between an active GTP-bound state on early endosomes and the plasma membrane and an inactive cytoplasmic GDP-bound form, coordinating vesicle docking through effectors such as EEA1 and Rabaptin-5.

Supplied as 50 µl of unconjugated antibody in a vial with TBS (pH 7.4), 1% BSA, 40% glycerol, and 0.05% sodium azide preservative. Validated for western blot and immunohistochemistry on human, mouse, and rat samples, supporting studies of membrane trafficking, synaptic vesicle recycling, endocytic signaling, and Rab GTPase regulation in cell biology research.

For best stability, store at -20°C and divide into working aliquots to limit freeze-thaw cycles; the glycerol formulation also permits short-term handling at -80°C. Investigators in neuroscience and cell biology use this clone to probe endocytic pathway components and vesicular transport mechanisms.