Anti-Rab4A Antibody

The Rab4A target is a small Ras-related GTPase that orchestrates cargo retrieval from early endosomes and governs the rapid recycling of membrane receptors, including the transferrin receptor, back to the plasma membrane. This recombinant rabbit monoclonal antibody from Antibodies.com binds the Rab4A protein in human, mouse, and rat samples and is supplied as an unconjugated reagent in 100 µl of TBS (pH7.4) supplemented with 1% BSA, 40% glycerol, and 0.05% sodium azide as a preservative.

The reagent is validated for Western blot and immunocytochemistry/immunofluorescence workflows, supporting studies of endocytic recycling, receptor trafficking, and signal attenuation downstream of receptor tyrosine kinases. Store at -20 degrees C in working aliquots to minimize repeated freeze-thaw cycles, and protect from light to preserve antibody activity over its shelf life. Because Rab4A coordinates early endosome sorting and influences the duration of cell-surface signaling, this reagent is used to characterize recycling phenotypes in cultured mammalian cells, primary neurons, and tissue sections, and it complements co-localization studies with markers such as EEA1, Rab5, and Rab11 to map distinct stages of the endosomal system.