Anti-Pyruvate Dehydrogenase E1 alpha Antibody

This polyclonal antibody from Antibodies.com targets the E1 alpha subunit of the pyruvate dehydrogenase complex (PDH E1α), the catalytic component responsible for decarboxylating pyruvate in the link between glycolysis and the citric acid cycle. Raised in rabbit and supplied as an unconjugated 100 µl volume, the reagent is validated for western blot and immunofluorescence workflows on human samples. Researchers studying mitochondrial metabolism, aerobic energy conversion, and PDH complex regulation commonly use PDHA1-targeting antibodies to probe expression patterns and post-translational modifications such as phosphorylation at serine residues that control enzymatic activity. The unconjugated format allows flexible pairing with secondary reporters, while the polyclonal profile provides broader epitope coverage useful when screening across PDH regulatory states. Each vial supports multiple experimental runs depending on dilution, and aliquoting is recommended to limit repeated freeze-thaw cycles and preserve binding performance over the antibody's working shelf life.