Anti-Pyruvate Dehydrogenase (C-term) Antibody

This Mouse monoclonal IgG1 antibody from Antibodies.com targets the C-terminal region of pyruvate dehydrogenase, the rate-limiting mitochondrial enzyme complex that converts pyruvate to acetyl-CoA and links cytosolic glycolysis to the citric acid cycle. Supplied as 100 µl of unconjugated reagent, the antibody is validated for western blot and immunocytochemistry workflows and shows reactivity with human, canine, rat, and mouse samples, making it useful for cross-species comparative studies of cellular metabolism, mitochondrial biogenesis, and PDH complex subunit composition.

The C-terminal epitope positions the reagent to detect full-length E1, E2, or E3 subunits of the multi-enzyme complex depending on isoform processing in the sample, supporting research into PDH deficiency disorders, cancer metabolism rewiring, and oxidative phosphorylation regulation. Researchers working on metabolic flux analysis, mitochondrial respiration, or studies of thiamine-dependent decarboxylation can pair this primary antibody with appropriate secondary reagents for protein expression profiling. Handle the vial on ice during use and avoid repeated freeze-thaw cycles by making single-use aliquots before long-term storage.