Anti-PYGM Antibody

The Antibodies.com polyclonal antibody targets glycogen phosphorylase (muscle form), the cytosolic enzyme that liberates glucose-1-phosphate from muscle glycogen during glycogenolysis. Validated for Western blot and immunohistochemistry workflows on human and mouse samples, this unconjugated rabbit reagent provides flexibility in selecting HRP, biotin, or fluorophore-conjugated secondaries and chromogen detection systems.

PYGM is highly expressed in skeletal muscle, where it governs energy mobilization during contraction, and pathogenic variants in the gene are the established cause of McArdle disease (glycogen storage disease type V). The 100 µL format supplies enough reagent for multiple immunoblots or a series of paraffin-embedded tissue sections, supporting investigations into inherited metabolic myopathies, exercise-induced muscle fatigue, glycogen metabolism, comparative cross-species expression profiling, and validation of muscle-derived cell models.