Anti-PVR Antibody

The poliovirus receptor (PVR), also known as CD155, is a transmembrane glycoprotein belonging to the nectin-like family of cell adhesion molecules. This unconjugated rabbit polyclonal reagent is raised against the human PVR target and is validated for western blot (WB) and immunohistochemistry (IHC) workflows. Each vial is supplied at 100 µl, suitable for routine immunolabeling of endogenous PVR expression in cultured human cells and formalin-fixed tissue sections.

PVR is expressed on epithelial, endothelial, and immune cell populations and serves as a ligand for both activating receptor DNAM-1 (CD226) and inhibitory receptors TIGIT and CD96, making it a molecule of significant interest in tumor immunology and immune checkpoint research. Researchers investigating NK cell and cytotoxic T cell activity, viral entry mechanisms, or cell-cell adhesion phenomena use Anti-PVR Antibody from Antibodies.com to detect endogenous receptor levels across human samples.

Handling guidance: store refrigerated in working aliquots and minimize freeze-thaw cycles to preserve antibody activity across repeated experimental sessions. The polyclonal format provides recognition of multiple epitopes on the PVR ectodomain and cytoplasmic tail, supporting broader detection coverage than monoclonal alternatives in exploratory assays and validation studies.