Anti-PURA Antibody

This Antibodies.com rabbit polyclonal antibody specifically recognizes PURA (Purine-Rich Element-Binding Protein A), a single-stranded DNA- and RNA-binding protein encoded on chromosome 5q31.2 that participates in DNA replication, transcriptional regulation, and mRNA translation. Supplied as 100 µg of liquid IgG, unconjugated, the reagent has been validated for western blot (WB), immunoprecipitation (IP), and immunofluorescence (IF) detection of PURA in human and mouse samples. PURA plays a critical role in neuronal development, and heterozygous mutations in the PURA gene cause PURA syndrome (also known as MRD31), a neurodevelopmental disorder characterized by neonatal hypotonia, intellectual disability, and early-onset seizures, making this antibody valuable for studies of neurogenesis, RNA transport granules, and transcriptional control in disease models. Store the vial refrigerated, protect from light, and aliquot to limit freeze-thaw cycles. For research use only.