Anti-PTX3 Antibody

Targeting pentraxin 3 (PTX3), a long pentraxin family member and soluble pattern recognition molecule of the innate immune system, this unconjugated reagent is offered by Antibodies.com as a 100 µl preparation of rabbit polyclonal IgG. PTX3 is rapidly induced at local sites of inflammation by cytokines such as IL-1β and TNF-α and has been investigated as a biomarker in sepsis, acute lung injury, atherosclerosis, and other vascular inflammatory conditions. The antibody has been validated for use on human and mouse samples, supporting comparative studies between the two species. Recommended applications include western blot detection of the approximately 42 kDa glycoprotein in cell lysates and immunofluorescence localization in cultured cells or frozen tissue sections. The polyclonal format provides coverage of multiple epitopes on the pentraxin domain, which can help when probing truncated or post-translationally modified forms of the target. Keep the vial refrigerated, protect it from light, and aliquot to limit repeated freeze-thaw damage to the IgG preparation.