Anti-Ptx3 Antibody

Pentraxin 3 (Ptx3) is a secreted pattern recognition receptor belonging to the long pentraxin family, strongly induced by inflammatory cytokines such as IL-1β and TNF-α and released by macrophages, dendritic cells, neutrophils, and vascular endothelial cells during infection or tissue injury. The reagent from Antibodies.com is an unconjugated rabbit polyclonal reagent targeting the Ptx3 protein, supplied at 100 µl and validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows in studies of human and mouse samples.

Ptx3 binds complement component C1q to drive classical pathway activation and opsonizes selected microbial surfaces, supporting research into innate immune signaling, vascular inflammation, sepsis biomarkers, and tumor microenvironment remodeling. The polyclonal antibody format detects the secreted glycoprotein in conditioned cell culture media, whole-cell lysates, and fixed tissue sections, making it useful for both basic and translational investigations. The product is intended for research use only.