Anti-PTTG1 Antibody

A rabbit polyclonal IgG reagent targeting PTTG1, the pituitary tumor-transforming protein also known as securin, supplied unconjugated in a 50 µL vial by Antibodies.com. PTTG1 regulates sister chromatid separation during anaphase by inhibiting separase, and its dysregulation is widely studied in pituitary adenomas as well as thyroid, breast, and colorectal tumor models. The antibody is validated for Western blot and immunohistochemistry workflows and cross-reacts with human, mouse, and rat samples, supporting comparative work between cultured cell lines and patient-derived tissue. Investigators focused on mitotic checkpoint failure, aneuploidy, securin–separase dynamics, and PTTG1's role as a proliferation marker in endocrine and epithelial cancers use this polyclonal reagent. Aliquot upon arrival and store refrigerated; the unconjugated IgG format pairs readily with HRP- or fluorophore-conjugated secondary antibodies for flexible detection.