Anti-PTRH2 Antibody

This rabbit polyclonal antibody from Antibodies.com targets PTRH2 (Peptidyl-tRNA Hydrolase 2), a mitochondrial enzyme also known as BIT1 that performs quality control on peptidyl-tRNA during translation and, upon release from depolarized mitochondria, suppresses anchorage-dependent survival through a caspase-independent pathway involving Grb2 and Erk signaling.

The reagent is supplied as 100 µl of a 1 mg/ml stock formulated in PBS with 0.1% sodium azide and 50% glycerol, and is unconjugated so researchers can pair it with their preferred secondary reagent. It has been validated for Western blot and immunohistochemistry applications and cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies across cultured cells, primary tissue, and rodent disease models.

Typical uses include probing apoptotic signaling cascades, mapping mitochondrial stress responses, and characterizing BIT1 release during tumor progression or neurodegeneration studies. For best results, store aliquots frozen at -20°C, avoid repeated freeze-thaw cycles, and protect from light to preserve antibody integrity.