Anti-PTPN2 Antibody

PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2), also called TC-PTP, is a cytoplasmic phosphatase that controls JAK-STAT cytokine signaling by dephosphorylating JAK1, JAK3, and downstream STAT proteins. This rabbit polyclonal reagent from Antibodies.com is supplied at 100 µL and validated for western blot, immunohistochemistry, and immunofluorescence in human, mouse, and rat samples.

PTPN2 acts as a critical negative regulator of cytokine receptor output in immune and hematopoietic cells, and PTPN2 loss-of-function variants are linked to autoimmune susceptibility and to certain hematologic malignancies. Researchers use unconjugated polyclonal anti-PTPN2 antibodies to monitor endogenous expression in whole-cell lysates, fixed tissue sections, and cultured cells, pairing the reagent with HRP-, biotin-, or fluorophore-conjugated secondary antibodies as their workflow requires.

For handling, store the vial at -20 °C in working aliquots, limit freeze-thaw cycles, and protect from light. The unconjugated format keeps the antibody compatible with most common detection chemistries and imaging platforms.