Anti-PTPN18 Antibody

PTPN18 (protein tyrosine phosphatase non-receptor type 18) is a non-receptor tyrosine phosphatase implicated in HER2/EGFR signaling attenuation, T-cell receptor signaling, and cytoskeletal remodeling. This rabbit polyclonal reagent from Antibodies.com was raised against human PTPN18 and is supplied as an unconjugated IgG in a 200 µl volume, ready for direct use or for conjugation to enzymes and fluorophores in custom detection assays.

The antibody is validated for Western blot detection of endogenous PTPN18 in human cell lysates and tissue homogenates, supporting research in cancer cell signaling, lymphocyte activation, and receptor tyrosine kinase pathway crosstalk. The polyclonal format recognizes multiple epitopes on the target phosphatase, increasing the likelihood of detecting post-translational modifications or splice variants.

For handling, the antibody should be stored refrigerated; aliquot upon arrival and freeze at -20 °C for long-term storage. Repeated freeze-thaw cycles should be avoided to preserve binding activity. As an unconjugated primary antibody, it pairs with standard anti-rabbit IgG secondary reagents for chemiluminescent or fluorescent readouts in Western blot workflows.