Anti-PTPN11 (phospho Y580) Antibody

This rabbit polyclonal IgG antibody from Antibodies.com selectively recognizes PTPN11 when phosphorylated at tyrosine 580, a regulatory site on the SHP-2 tyrosine phosphatase implicated in RAS-MAPK signaling, Noonan syndrome, and juvenile myelomonocytic leukemia research. Supplied as 50 µl of unconjugated serum, the reagent is validated for immunohistochemistry on formalin-fixed paraffin-embedded tissue sections and cross-reacts with human, mouse, and rat samples. The polyclonal backbone allows recognition of multiple epitopes surrounding the phospho-Y580 residue, supporting clear signal in tissues where phosphorylated SHP-2 accumulates at activated receptor complexes, focal adhesions, or within leukemic cell populations under study. Store at -20°C in aliquots to preserve phospho-specific binding across repeated freeze-thaw cycles, and pair with HRP- or fluorophore-conjugated secondary antibodies for chromogenic or fluorescence detection in cell signaling workflows.