Anti-PTPN11 Antibody

The PTPN11 gene encodes the SHP-2 tyrosine phosphatase, a critical regulator of RAS/MAPK and PI3K signaling cascades frequently studied in Noonan syndrome, LEOPARD syndrome, and juvenile myelomonocytic leukemia research. This rabbit polyclonal reagent from Antibodies.com is raised against human PTPN11 and enables sensitive detection of the endogenous protein across multiple experimental workflows.

Validated for Western blot, immunohistochemistry, and flow cytometry, the unconjugated IgG preparation offers flexibility to pair with standard secondary antibodies for chromogenic or fluorescent readouts. Each vial contains 200 µl of polyclonal antiserum for probing lysates, fixed tissue sections, and cell suspensions.

The polyclonal format supports recognition of multiple epitopes on the SHP-2 protein, helping researchers resolve expression patterns and pathway activity in cell signaling studies, cancer models, and developmental biology investigations.