Anti-PTPN11 Antibody

The PTPN11 gene encodes the cytoplasmic tyrosine phosphatase SHP-2, a broadly expressed regulator of receptor tyrosine kinase signaling and a key node in the RAS/MAPK cascade. Loss- and gain-of-function changes in this phosphatase are linked to Noonan syndrome, LEOPARD syndrome, and juvenile myelomonocytic leukemia, making dependable detection reagents important for both basic signaling studies and disease-model research.

Available through Antibodies.com, this unconjugated rabbit polyclonal reagent is raised against PTPN11 and validated for Western blot and immunohistochemistry on human and mouse samples. It is supplied as 100 µl of liquid stock, with no fluorophore or enzyme conjugate attached, so researchers can pair it with their own preferred secondary detection chemistry. The polyclonal format offers multi-epitope recognition, which can help when probing mutant isoforms, truncated variants, or partially degraded lysate preparations commonly encountered in signaling and oncology workflows.