Anti-PTPN1 Antibody

PTPN1 encodes PTP1B, a non-transmembrane protein tyrosine phosphatase anchored to the cytoplasmic face of the endoplasmic reticulum, where it negatively regulates insulin and leptin receptor signaling cascades. This rabbit polyclonal antibody from Antibodies.com is raised against PTPN1 and validated for western blot and immunofluorescence across human, mouse, and rat samples.

The unconjugated reagent is supplied as a 50 µL vial and is intended for immunoblotting of cleared cell or tissue lysates as well as for visualizing endogenous PTP1B distribution in fixed cells. Storage at -20 °C in working aliquots is recommended to preserve antibody activity through repeated freeze-thaw cycles, and the product is intended for research use only.

Because PTP1B acts as a key negative regulator of insulin and leptin pathways, this reagent is frequently used in metabolic, obesity, and signal transduction research, supporting studies of receptor desensitization, ER-associated phosphatase function, and downstream MAPK and PI3K signaling responses in cultured cells and primary tissue.