Anti-PTK2B Antibody

PTK2B (also known as PYK2, FAK2, or calcium-dependent tyrosine kinase) is a non-receptor cytoplasmic protein tyrosine kinase activated by intracellular calcium concentration changes and integrin engagement. This unconjugated rabbit polyclonal Primary Antibody targets PTK2B and is supplied by Antibodies.com as 100 µl of liquid reagent validated for western blot (WB) and immunohistochemistry (IHC) on human samples.

The antibody recognizes the PTK2B protein, a kinase that drives cytoskeletal reorganization, focal adhesion turnover, and downstream MAPK and PI3K signaling. PTK2B participates in osteoclast differentiation and bone resorption, neuronal ion-channel regulation, and mechanotransduction in vascular and immune cells, making this reagent useful in oncology, neuroscience, and bone biology research.

Raised in rabbit, the polyclonal antiserum contains a heterogeneous population of immunoglobulins directed at multiple epitopes on human PTK2B, increasing the likelihood of detection across varied experimental conditions. The unconjugated format allows laboratories to pair this Primary Antibody with their preferred secondary detection system, including HRP, alkaline phosphatase, or fluorophore conjugates, depending on whether they run chromogenic western blot membranes or fluorescent IHC imaging workflows. The vial is shipped refrigerated on arrival and the reagent is intended for research use only.