Anti-PTK2 (phospho Y576 + Y577) Antibody

The Antibodies.com polyclonal antibody targets PTK2, also known as Focal Adhesion Kinase (FAK), at the doubly phosphorylated activation loop residues Y576 and Y577. These adjacent tyrosines in the catalytic domain become phosphorylated during integrin-mediated adhesion and downstream of Src family kinases, correlating with maximal enzymatic activity. The rabbit IgG reagent is supplied unconjugated at 200 µl and validated for Western blot detection of the human PTK2 protein in its active, phosphorylated state. Researchers studying focal adhesion turnover, cytoskeletal remodeling, cell migration, and metastatic signaling pathways use this reagent to distinguish activated FAK from the unphosphorylated baseline in cell lysates and tissue extracts.