Anti-PTK2 Antibody

The PTK2 gene encodes Focal Adhesion Kinase (FAK), a non-receptor tyrosine kinase that localizes to sites of integrin-mediated cell adhesion and orchestrates signaling cascades controlling cytoskeletal remodeling, cell migration, and survival.

This rabbit polyclonal IgG reagent from Antibodies.com is supplied as an unconjugated 50 µl vial and targets the endogenous PTK2 protein in human and rat samples. Validated applications cover western blot analysis of cell and tissue lysates and immunohistochemistry on formalin-fixed paraffin-embedded sections, supporting studies of focal adhesion dynamics, integrin signaling, and tumor invasion biology.

The polyclonal format recognizes multiple epitopes across the FAK molecule, providing broader detection of the full-length kinase and commonly studied phospho-forms when probed against activated samples. Researchers investigating epithelial-mesenchymal transition, metastatic dissemination, or mechanotransduction pathways use this reagent to map FAK expression across normal epithelium, carcinoma specimens, and neuronal tissues where PTK2 activity has been linked to developmental signaling.