Anti-PTK2 Antibody

Raised in rabbit against the 125 kDa non-receptor tyrosine kinase PTK2 (Focal Adhesion Kinase), this polyclonal IgG reagent from Antibodies.com ships as a 100 µl vial of unconjugated antibody. The reagent detects full-length PTK2 across human, mouse, and rat samples in western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows. Because PTK2 concentrates at integrin-rich focal adhesion plaques and autophosphorylates at Tyr397 upon matrix engagement, researchers use it to track adhesion-dependent signaling downstream of extracellular cues. Oncology groups apply the antibody to profile FAK expression and phosphorylation in tumor biopsies of breast, ovarian, and pancreatic origin, where elevated PTK2 levels correlate with invasive phenotypes and reduced patient survival. Cell biology labs exploit the polyclonal format to recognize phospho-modified or truncated variants, including the autonomously expressed FRNK repressor isoform, that monoclonal reagents often miss. Each 100 µl vial provides ample reagent for multiple immunoblots and staining protocols.