Anti-PTH1R Antibody

PTH1R, the parathyroid hormone 1 receptor, is a class B G protein-coupled receptor that mediates calcium homeostasis and bone remodeling through PTH and PTH-related protein (PTHrP) signaling. The unconjugated rabbit polyclonal antibody from Antibodies.com (Anti-PTH1R) is supplied at 100 µl and validated for western blot (WB) and immunohistochemistry (IHC) on human and rat samples, supporting research in endocrinology, skeletal biology, and signal transduction. Reagent handling follows standard practice: aliquot on arrival to limit freeze-thaw cycles, refrigerate for short-term use, and freeze for longer retention. The antibody detects PTH1R in tissue sections and on immunoblots, enabling visualization of receptor expression in kidney, bone, and cartilage models. Its polyclonal format recognizes multiple epitopes on the receptor, an advantage when samples may contain splice variants or post-translational modifications that affect single-epitope detection. Researchers studying PTH1R-mediated cAMP signaling, osteoblast and osteoclast activity, or renal tubular calcium transport will find this reagent useful. It is intended for research use only and is not validated for diagnostic or therapeutic applications.