Anti-PTH Antibody

Targeting parathyroid biology, this unconjugated rabbit polyclonal antibody recognizes human Parathyroid Hormone (PTH), the 84-amino acid, ~9.4 kDa calcium-regulating peptide secreted by chief cells of the parathyroid glands. Supplied by Antibodies.com as 100 µl of polyclonal serum, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and binds PTH expressed in human tissue samples. Researchers apply anti-PTH antibodies to investigate primary and secondary hyperparathyroidism, hypoparathyroidism, parathyroid adenoma and carcinoma pathology, and the bone-mineral disturbances seen in chronic kidney disease, where altered PTH cleavage fragment patterns are clinically relevant. The polyclonal format broadens epitope coverage along the PTH(1-84) backbone and the circulating mid-molecule and C-terminal fragments, which is useful when probing fixed parathyroid and bone tissue sections in IHC. PTH acts through the PTH1 receptor on bone and kidney to maintain serum calcium, and this reagent supports studies that connect gland-level hormone expression with downstream skeletal and renal readouts.