Anti-PTEN (phospho S370) Antibody

The PTEN tumor suppressor is regulated through post-translational phosphorylation, and the serine 370 site within its C-terminal tail has been investigated in the context of CK2-mediated modification, protein stability, and membrane association with downstream PI3K/AKT signaling. This rabbit polyclonal reagent from Antibodies.com recognizes PTEN only when phosphorylated at S370, giving researchers a phospho-specific tool for Western blot analysis of tumor suppressor and kinase signaling pathways in human samples. The antibody is supplied as 100 µl of unconjugated IgG raised in rabbit, in a vial format suitable for detection of endogenous PTEN in cell lysates and tissue homogenates. Because it is polyclonal, it offers broader recognition across the modified epitope, which can be advantageous when probing endogenous phosphorylation levels under different stimulation, inhibitor, or treatment conditions. Researchers studying PI3K/AKT pathway regulation, PTEN tumor suppressor biology, or kinase-dependent signaling crosstalk can use this reagent to track S370 phosphorylation status across experimental time courses and conditions.