Anti-PTEN (D386) Antibody

PTEN (Phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase and tumor suppressor that antagonizes the PI3K/AKT signaling cascade. This unconjugated rabbit polyclonal reagent from Antibodies.com targets the D386 region of human PTEN, supporting detection by western blot and immunohistochemistry in human, mouse, and rat samples.

Supplied as 100 µl at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.2, the antibody finds application in research examining PTEN loss in prostate, endometrial, breast, and glioblastoma models, as well as Cowden syndrome and PTEN hamartoma tumor studies. Storage at 4 °C is recommended for short-term use; aliquoting helps preserve performance across multiple experiments.