Anti-PTEN Antibody

Raised in rabbit and supplied by Antibodies.com as an unconjugated reagent in a 100 µl volume, this polyclonal primary antibody targets PTEN (phosphatase and tensin homolog), a lipid phosphatase that acts as a critical negative regulator of the PI3K/AKT signaling pathway. PTEN is among the most frequently inactivated tumor suppressors in human cancer, and this reagent is validated for western blot, immunohistochemistry, and ELISA applications with documented reactivity against human, mouse, and rat samples. Investigators studying prostate, endometrial, breast, and glioblastoma malignancies — where biallelic PTEN loss drives aberrant growth signaling — use the antibody to assess protein expression, localize tissue distribution, and confirm genetic findings at the protein level. The polyclonal format provides recognition of multiple epitopes across the PTEN protein, which is useful when working with truncated or mutant forms that may escape monoclonal reagents. Storage at -20 °C in working aliquots is recommended to preserve lot-to-lot performance across repeated freeze-thaw cycles, and brief centrifugation prior to use helps recover material from the vial walls.