Anti-PTEN Antibody

PTEN (Phosphatase and tensin homolog) is a critical tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway by dephosphorylating PIP3 to PIP2. Loss of PTEN function is implicated in numerous human cancers, including glioblastoma, endometrial carcinoma, and prostate cancer, as well as in Cowden syndrome, where germline mutations predispose patients to hamartomas and malignancies. This unconjugated rabbit polyclonal antibody from Antibodies.com supports investigation of PTEN localization and abundance across experimental platforms.

Reactivity extends to human, mouse, and rat PTEN, and the antibody is listed for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows. Each vial contains 100 µL of polyclonal reagent, appropriate for cell signaling studies, apoptosis assays, and tumor suppressor research. Store at -20 degrees C, protect from light, and aliquot upon receipt to minimize freeze-thaw cycles.