Anti-PTEN Antibody

PTEN (Phosphatase and tensin homolog) is a critical tumor suppressor that negatively regulates the PI3K/AKT signaling cascade by dephosphorylating PIP3 to PIP2. Loss of PTEN function is a hallmark of many cancers, including prostate, endometrial, and glioblastoma, and is implicated in Cowden syndrome.

This rabbit polyclonal antibody from Antibodies.com targets PTEN and is validated for Western blot and immunohistochemistry applications. It detects the endogenous protein in human, mouse, and rat samples, supporting studies of tumor suppressor biology, cancer signaling pathways, and metabolic regulation in cell lysates.

The unconjugated reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, with a 50 µl volume suitable for multiple Western blot and IHC experiments. Researchers commonly use this antibody to investigate PI3K/AKT pathway activity, evaluate PTEN status in tumor tissue sections, and probe signaling mechanisms underlying proliferation, apoptosis, and insulin response.