Anti-PTCH1 Antibody

The rabbit polyclonal antibody from Antibodies.com targets the PTCH1 protein, a 12-pass transmembrane receptor that functions as a key negative regulator of the Hedgehog signaling pathway and serves as the primary receptor for Sonic Hedgehog ligands.

Supplied as 100 µl of polyclonal antiserum raised in rabbit and unconjugated, the reagent is validated for Western blot and immunohistochemistry on human and mouse samples, supporting workflows with cell culture lysates and paraffin-embedded tissue sections.

PTCH1 is widely studied as a tumor suppressor whose loss-of-function mutations underlie Gorlin syndrome and drive sporadic basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, making sensitive detection of the protein valuable for oncogenesis, developmental biology, and Hedgehog pathway research. Investigators apply this reagent to characterize pathway activity and to examine expression patterns relevant to embryonic patterning, neural tube development, and adult stem cell populations.

The polyclonal format offers broad epitope recognition across PTCH1, supporting reproducible signal generation on blotting membranes and in stained tissue sections in diverse experimental conditions such as those involving skin, neural, or tumor-derived specimens.