Anti-PTCH1 Antibody

PTCH1 (Patched 1) is a transmembrane receptor that serves as a key negative regulator of the Hedgehog (Hh) signaling pathway, a developmental cascade implicated in cell differentiation, tissue patterning, and tumor biology. Loss-of-function mutations in PTCH1 are causally linked to Gorlin syndrome and sporadic basal cell carcinoma, while broader pathway dysregulation contributes to medulloblastoma and rhabdomyosarcoma, making the protein a frequent target in cancer research and developmental studies.

This rabbit polyclonal antibody from Antibodies.com recognizes the human and mouse PTCH1 protein and is validated for western blot detection. Supplied as 50 µl of unconjugated IgG in a vial, the reagent supports laboratories investigating Hedgehog pathway activity, stem cell regulation, and oncology models where PTCH1 expression levels serve as a relevant biomarker. For storage, keep the antibody at -20 °C in working aliquots to preserve binding activity across repeated freeze-thaw cycles, and minimize light exposure for long-term stability.