Anti-PTCH1 Antibody

This rabbit polyclonal IgG reagent from Antibodies.com targets PTCH1 (Patched 1), the twelve-transmembrane receptor that restrains Hedgehog pathway signaling and acts as a key tumor suppressor in basal cell carcinoma and medulloblastoma research. Supplied as a 200 µl liquid aliquot, the unconjugated antibody is validated for Western blot and cross-reacts with both human and mouse samples, supporting studies in developmental biology, oncogenesis, and Hedgehog pathway dissection.

The polyclonal format increases the chance of recognizing multiple epitopes on PTCH1, which is useful when probing full-length receptor versus cleaved fragments in cell lysate preparations. Researchers commonly apply this reagent at working dilutions optimized for chemiluminescent or near-infrared western detection of the ~161 kDa PTCH1 protein, allowing comparison of pathway activation states between normal and tumor-derived tissues. Store refrigerated short term and avoid repeated freeze-thaw cycles to preserve activity across extended western blot campaigns.