Anti-PTBP1 Antibody

PTBP1 (Polypyrimidine Tract Binding Protein 1) is a ~57 kDa RNA-binding protein of the hnRNP family that regulates pre-mRNA splicing, mRNA stability, polyadenylation, and IRES-mediated translation. This unconjugated rabbit polyclonal antibody from Antibodies.com binds the endogenous human, mouse, and rat PTBP1 polypeptide and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows. PTBP1 plays key roles in neuronal differentiation programs, metabolic tissue remodeling, and several oncogenic signaling pathways, making it a widely investigated target across neurobiology, developmental biology, and cancer research. The reagent is supplied as 100 µL of polyclonal antiserum; aliquot upon first use and store at -20°C, avoiding repeated freeze-thaw cycles to preserve binding activity. Polyclonal rabbit antibodies provide broader epitope coverage than monoclonals, supporting detection of PTBP1 isoforms, splice variants, and post-translationally modified species in cell lysates and tissue sections.