Anti-PSMF1 Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes PSMF1 (Proteasome Inhibitor Subunit 1, also called PI31), an endogenous regulator of the 26S proteasome. PSMF1 binds the 20S core particle and modulates proteasomal proteolytic activity, and the protein contributes to cellular protein homeostasis. Research on PSMF1 spans neurodegeneration models and tumor biology, where altered proteasome regulation is studied in contexts ranging from Alzheimer's disease to glioma and breast carcinoma cell behavior.

The reagent is supplied as an unconjugated liquid polyclonal preparation in a 100 µl volume and is validated for Western blot and immunohistochemistry on human samples. Researchers use it to probe endogenous PSMF1 expression in cell lysates and fixed tissue sections, to examine proteasome assembly states under proteotoxic stress, and to compare PSMF1 levels across tumor and normal specimens.

For handling, store the antibody frozen at -20 °C in working aliquots and avoid repeated freeze-thaw cycles to preserve binding activity; brief storage on ice is appropriate during active use. This reagent is intended for research use only and is not validated for diagnostic or therapeutic procedures.