Anti-PSME3 Antibody

Raised in rabbit against the PSME3 proteasome activator subunit, this unconjugated polyclonal reagent from Antibodies.com supports detection of the REGγ/PA28γ nuclear regulator across multiple experimental formats. Validated applications include Western blot, immunohistochemistry, and immunofluorescence, covering the workflows most labs use to probe proteasome activator expression in cultured mammalian cells and in fixed tissue sections.

Reactivity has been confirmed in human and rat samples, which makes the antibody useful for translational work that bridges patient-derived material with rodent model systems. The host species is rabbit and the reagent is supplied as 100 µl of unconjugated polyclonal Ig, ready for dilution into standard blocking buffers and for pairing with either HRP- or fluorophore-conjugated secondary antibodies.

PSME3, also called REGγ or PA28γ, binds 20S proteasome complexes in the nucleus and influences the turnover of regulatory proteins such as p21, p53, and MDM2, so it is frequently investigated in cell cycle, apoptosis, and cancer biology contexts. Researchers studying colorectal carcinoma, melanoma progression, or MHC class I antigen-processing pathways commonly choose this target, and the polyclonal format helps when capturing several isoforms or post-translational modifications at once. Storage at 4 °C short term, with aliquoting before freezing, preserves reagent performance across repeated experiments.