Anti-PSME1 Antibody

Raised in rabbit against the proteasome activator subunit PSME1, this polyclonal reagent from Antibodies.com recognizes the PA28α component of the 11S regulator complex that caps the 20S proteasome and promotes MHC class I antigen processing. Supplied as 100 µl of unconjugated antiserum, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence detection in human, mouse, and rat samples.

PSME1 is inducible by interferon-γ and concentrates in the cytoplasm and nucleus of stimulated cells, where it modulates peptide cleavage and shapes the immunoproteasome repertoire. Researchers investigating antigen presentation, vaccine response models, and tumor immune microenvironment use this reagent to track expression changes across cell lines, primary immune cells, and formalin-fixed paraffin-embedded tissue sections.

For routine use, aliquot the antibody upon receipt and store at -20°C; protect from light and limit freeze-thaw cycles to maintain titer. The polyclonal format recognizes multiple epitopes on PSME1, supporting reproducible staining in IHC and crisp signal in immunofluorescence imaging of adherent and suspension cell cultures.