Anti-PSMD6 Antibody

Antibodies.com offers this rabbit polyclonal antibody that recognizes PSMD6, a non-ATPase regulatory subunit of the 26S proteasome lid subcomplex. PSMD6 contributes to the recognition and processing of polyubiquitinated substrates channeled through the ubiquitin-proteasome pathway, a system that governs protein turnover, cell cycle progression, and stress-related signaling in eukaryotic cells.

Supplied as an unconjugated polyclonal reagent at 100 µl per vial, the antibody is validated for western blot and immunohistochemistry applications. Reactivity has been confirmed with human and mouse samples, supporting comparative work across established cell line models, primary cultures, and tissue specimens from both species.

Typical uses include immunoblotting of whole-cell or tissue lysates to assess PSMD6 expression and incorporation into proteasome assemblies, as well as immunohistochemical localization in fixed paraffin-embedded or frozen tissue sections. The reagent is suited to laboratories investigating proteasome composition, misfolded protein clearance, and pathways linked to neurodegenerative disease, cancer biology, and inflammatory responses.