Anti-PSMC2 Antibody

Produced in rabbit and supplied at 200 µl per vial, this unconjugated IgG polyclonal antibody from Antibodies.com recognizes PSMC2, the ATPase subunit (Rpt1) of the 19S regulatory particle that caps the eukaryotic 26S proteasome. PSMC2 supplies the ATP-driven power stroke that unfolds polyubiquitinated substrates and feeds them into the 20S catalytic core, so the reagent is widely used in protein turnover research and ubiquitin–proteasome pathway studies. The antibody is validated for Western blot and has been confirmed to react with human and mouse samples, supporting cross-species work in cancer cell lines, primary tissue lysates, and neurodegeneration models that examine proteasome composition and stress signaling. Aliquot upon receipt, store refrigerated, and minimize freeze-thaw cycles to preserve binding activity across multiple blots. The polyclonal format provides broad recognition of the full-length PSMC2 protein under denaturing SDS-PAGE conditions and tolerates minor variation between isoforms. Researchers can pair this reagent with standard HRP or fluorescent secondaries depending on the detection platform, and use it to assess 19S subunit abundance, proteasome assembly state, and changes in ATPase subunit expression under proteotoxic or proteasome-inhibitor treatment conditions.