Anti-PSMC1 Antibody

Raised in rabbit against the PSMC1 subunit of the 26S proteasome, this unconjugated polyclonal antibody from Antibodies.com is supplied as 100 µl of liquid reagent and is validated for western blot and immunohistochemistry workflows. The 26S proteasome is the ATP-dependent complex responsible for most regulated protein turnover in eukaryotic cells, and PSMC1 (also called p56) is one of six AAA-ATPase subunits that form the proteasomal regulatory particle, driving substrate unfolding and translocation into the 20S core. Researchers studying proteasome assembly, ubiquitin-dependent degradation, and protein homeostasis use this reagent to detect endogenous PSMC1 in human, mouse, and rat samples, supporting work in cell biology, cancer biology, and models of neurodegeneration where altered proteasome activity has been implicated. As a polyclonal reagent, it offers broad epitope coverage on the target, which can be useful when probing denatured lysates by WB or fixed tissue sections by IHC. The unconjugated format allows flexibility to pair it with a secondary antibody or label of the researcher's choice, and the 100 µl vial size is well matched to exploratory experiments and pilot studies.