Anti-PSMB8 Antibody

PSMB8 (Proteasome Subunit Beta 8), also known as LMP7, is a catalytic subunit of the immunoproteasome, an inducible form of the 20S proteasome that is upregulated in immune cells in response to interferon signaling. It plays a central role in generating peptide ligands for MHC class I molecules and shaping antigen presentation to cytotoxic T lymphocytes. Loss-of-function and expression changes in PSMB8 have been linked to autoinflammatory conditions such as Nakajo-Nishimura syndrome and JMP, making it a target of interest in immunology, inflammation, and oncology research.

This rabbit polyclonal reagent is unconjugated and validated for western blot, immunohistochemistry, and immunofluorescence workflows on human specimens. Supplied as 100 µl of antiserum, it is suitable for immunoblotting of cell or tissue lysates, IHC staining of formalin-fixed paraffin-embedded sections, and IF imaging of cultured cells. The antibody works with standard secondary detection reagents, including HRP- and fluorophore-conjugated anti-rabbit IgG.

Researchers studying antigen processing, MHC class I peptide loading, and interferon-gamma signaling routinely rely on anti-PSMB8 antibodies. Applications also include tumor immunogenicity profiling, immune cell differentiation studies, and evaluation of immunoproteasome inhibitors. For long-term use, the product should be stored at -20 °C, with working aliquots kept refrigerated and protected from repeated freeze-thaw cycles to preserve binding activity.

From Antibodies.com, this polyclonal reagent serves as a practical tool for laboratories characterizing proteasome subunit composition, antigen presentation defects, and inflammatory disease models.