Anti-PSMB4 Antibody

The PSMB4 protein (Proteasome 20S Subunit Beta 4) is a constituent beta subunit of the 20S core particle that contributes to ubiquitin-dependent protein degradation in eukaryotic cells. This unconjugated rabbit polyclonal antibody from Antibodies.com targets PSMB4 for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples, making it a useful reagent for studying proteasome assembly, cellular protein homeostasis, and the PSMB4 overexpression that has been documented in hepatocellular carcinoma, breast cancer, and cholangiocarcinoma.

Validated for WB, IHC, and IF applications, the reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit, unconjugated for flexible pairing with secondary detection chemistries such as HRP or fluorophore conjugates. In standard denaturing gels, the target migrates near 29 kDa, providing a clear read-out when probing whole-cell lysates or tissue extracts. Researchers investigating NF-κB pathway regulation, ER-associated degradation, MHC class I antigen processing, or the proteasome subunit repertoire in disease models can rely on broad reactivity across the three listed species. Aliquot upon arrival and store refrigerated to preserve titer across multiple experiments, avoiding repeated freeze-thaw cycles.