Anti-PSMA1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets PSMA1 (Proteasome Subunit Alpha 1), a core component of the 20S proteasome involved in ubiquitin-dependent protein degradation. Raised in rabbit and supplied as an unconjugated reagent in a 100 µl volume, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) workflows. It cross-reacts with human, mouse, and rat samples, making it useful for comparative studies across model organisms and human tissue specimens.

PSMA1 contributes to the assembly of the proteasome alpha ring and participates in regulated proteolysis linked to cell cycle progression, antigen processing, and cellular stress responses. Researchers use anti-PSMA1 reagents to investigate proteasome biogenesis, monitor changes in proteasomal subunit composition under disease or treatment conditions, and assess the distribution of 20S complexes in fixed tissue sections.

Polyclonal reactivity provides recognition of multiple epitopes on the alpha 1 subunit, supporting detection of full-length protein as well as potential proteolytic fragments. Store the vial refrigerated and protect from light to preserve antibody activity across multiple freeze-thaw cycles. The unconjugated format allows flexibility in downstream labeling, including HRP, biotin, or fluorophore conjugation tailored to specific experimental designs.